MicroRNA delivery mediated by PEGylated polyethylenimine for prostate cancer therapy
نویسندگان
چکیده
منابع مشابه
Investigating lipopolymers based on polyethylenimine and nanoliposome for gene delivery to prostate cancer (PC3) cell line
Background: Non-viral Nano carriers such as liposomes and cationic polymers based on engineered properties are regarded in gene delivery field. Although these carriers do not have weaknesses of viral vectors, but they are less efficient than viruses and they still need to be improved as favorable gene delivery carriers. Amongst non-viral carriers, cationic liposomes have been proposed for clini...
متن کاملMicroRNA delivery by cationic lipoplexes for lung cancer therapy.
Lung cancer is the leading cause of cancer deaths in western countries and carries a poor overall five year survival rate. Several studies demonstrate that microRNAs (miRNAs or miRs) are actively involved in tumor development by serving as tumor suppressors, oncogenes or both. In lung cancer, miRNAs may serve as both diagnostic and prognostic biomarkers as well as regulate in vitro and in vivo ...
متن کاملOncolytic adenovirus-mediated therapy for prostate cancer
Prostate cancer is a leading cause of cancer-related death and morbidity in men in the Western world. Tumor progression is dependent on functioning androgen receptor signaling, and initial administration of antiandrogens and hormone therapy (androgen-deprivation therapy) prevent growth and spread. Tumors frequently develop escape mechanisms to androgen-deprivation therapy and progress to castra...
متن کاملSystemic Delivery of Nucleic Acids for Prostate Cancer Therapy
Background Nucleic acids are emerging as a novel class of therapeutics for cancer treatment. For example, RNA interference (RNAi)based gene silencing has been widely used for identification and validation of putative cancer targets, and several RNAi nanotherapeutics are now under clinical trials in cancer patients. Messenger RNA (mRNA) has also shown unique advantages for the development of can...
متن کاملPolyethylenimine-mediated gene delivery to the lung and therapeutic applications
Nonviral gene delivery is now considered a promising alternative to viral vectors. Among nonviral gene delivery agents, polyethylenimine (PEI) has emerged as a potent candidate for gene delivery to the lung. PEI has some advantages over other polycations in that it combines strong DNA compaction capacity with an intrinsic endosomolytic activity. However, intracellular (mainly the nuclear membra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Open Chemistry
سال: 2018
ISSN: 2391-5420
DOI: 10.1515/chem-2018-0138